name: indication-dossier description: > Generate a therapeutic indication dossier. Covers the patient population, epidemiology, disease biology, standard of care, regulatory precedent, and landmark clinical trials. license: Apache-2.0
Indication Dossier
Produces a structured research dossier on a single indication, framed as a patient population: who they are, what's wrong, how they're treated today, and how clinical trials can be designed to help them. Runs as five phases that write resumable waypoint files; after a brief identity check at the end of Phase 1, the remaining phases run straight through.
Framing
Think of an indication as a patient population. Frame everything from the patient perspective: "Who are these patients?" not "What is this disease?"; "How are these patients identified and managed?" not "What causes this condition?"; population nesting: "all patients in {child} are patients in {parent}".
Some indications don't map to ICD codes or standard disease definitions: "immunosenescence" is a biological state, not a billable diagnosis; "ageing" is not an FDA-accepted indication; "GLP-1 induced sarcopenia" is an iatrogenic population. Note these distinctions explicitly. They matter for regulatory path and trial design.
Inputs
indication(required) — indication name (e.g., "sarcopenia", "idiopathic pulmonary fibrosis").additional_context(optional) — areas to focus on, parent indication, or other framing.workdir(optional) — where to write waypoints and the final report. Defaults to./do_not_commit/indication-dossier-<slug>/.