solublempnn

by aipoch5.0k

Install

The skill file stays in the publisher's repository.

Paste the copied command in a terminal. It installs this SKILL.md into that agent.

npx skills add aipoch/open-science --skill solublempnn -a cursor -y

Download skill resources/skills/solublempnn/SKILL.md on GitHub

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Questions

How do I install solublempnn?: Download resources/skills/solublempnn/SKILL.md from the publisher, or copy the path and open the repository. PlugMCP lists the skill and does not host the file.
Where does solublempnn live?: The publisher keeps it at https://github.com/aipoch/open-science.
Which agents can use solublempnn?: Claude, Cursor, and Codex can read a SKILL.md you add from the publisher's repository.

name: solublempnn description: > Inverse-fold a backbone with SolubleMPNN — ProteinMPNN retrained on a soluble-PDB subset (Dauparas et al. 2022) — for sequences biased toward cytosolic expression and reduced aggregation. Reach for this skill when designs from vanilla ProteinMPNN are aggregating or going to inclusion bodies, when redesigning a membrane-adjacent fold for soluble expression, or when an E. coli expression screen is the next step. license: Apache-2.0 category: biomodels metadata: display-name: SolubleMPNN

solublempnn

Install

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Questions

github.com/dauparas/ProteinMPNN/blob/main/LICENSE: MIT (© 2022 Justas

Dauparas). soluble_model_weights ship in the same repo with no separate

license. verified 2026-06-30

third_party: - kind: weights name: SolubleMPNN license: MIT terms_url: https://github.com/dauparas/ProteinMPNN/blob/main/LICENSE

SolubleMPNN

Running it

Hydrophobic surface patches still recur where the fold needs them

"Crystallisable" training set ≠ "soluble in your host" — keep an orthogonal filter